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Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo

Nod1 is a member of family of intracellular proteins that mediate host recognition of bacterial peptidoglycan. To characterize immune responses mediated by Nod1, synthetic ligand compounds possessing enhanced ability to stimulate Nod1 were developed to study the function of Nod1. Stimulation of epit...

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Autores principales: Masumoto, Junya, Yang, Kangkang, Varambally, Sooryanarayana, Hasegawa, Mizuho, Tomlins, Scott A., Qiu, Su, Fujimoto, Yukari, Kawasaki, Akiko, Foster, Simon J., Horie, Yasuo, Mak, Tak W., Núñez, Gabriel, Chinnaiyan, Arul M., Fukase, Koichi, Inohara, Naohiro
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118074/
https://www.ncbi.nlm.nih.gov/pubmed/16418393
http://dx.doi.org/10.1084/jem.20051229
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author Masumoto, Junya
Yang, Kangkang
Varambally, Sooryanarayana
Hasegawa, Mizuho
Tomlins, Scott A.
Qiu, Su
Fujimoto, Yukari
Kawasaki, Akiko
Foster, Simon J.
Horie, Yasuo
Mak, Tak W.
Núñez, Gabriel
Chinnaiyan, Arul M.
Fukase, Koichi
Inohara, Naohiro
author_facet Masumoto, Junya
Yang, Kangkang
Varambally, Sooryanarayana
Hasegawa, Mizuho
Tomlins, Scott A.
Qiu, Su
Fujimoto, Yukari
Kawasaki, Akiko
Foster, Simon J.
Horie, Yasuo
Mak, Tak W.
Núñez, Gabriel
Chinnaiyan, Arul M.
Fukase, Koichi
Inohara, Naohiro
author_sort Masumoto, Junya
collection PubMed
description Nod1 is a member of family of intracellular proteins that mediate host recognition of bacterial peptidoglycan. To characterize immune responses mediated by Nod1, synthetic ligand compounds possessing enhanced ability to stimulate Nod1 were developed to study the function of Nod1. Stimulation of epithelial cells with Nod1 stimulatory molecules induced chemokines and other proinflammatory molecules that are important for innate immune responses and recruitment of acute inflammatory cells. Administration of Nod1 ligands into mice induced chemokines and recruitment of acute inflammatory cells, an activity that was abolished in Nod1-null mice. Microarray analysis revealed that Nod1 stimulation induces a restricted number of genes in intestinal epithelial cells compared with that induced by tumor necrosis factor (TNF) α. Nod1 stimulation did not induce TNFα, interleukin 12, and interferon γ, suggesting that the primary role of Nod1 is to induce the recruitment of immune cells. These results indicate that Nod1 functions as a pathogen recognition molecule to induce expression of molecules involved in the early stages of the innate immune response.
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spelling pubmed-21180742007-12-13 Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo Masumoto, Junya Yang, Kangkang Varambally, Sooryanarayana Hasegawa, Mizuho Tomlins, Scott A. Qiu, Su Fujimoto, Yukari Kawasaki, Akiko Foster, Simon J. Horie, Yasuo Mak, Tak W. Núñez, Gabriel Chinnaiyan, Arul M. Fukase, Koichi Inohara, Naohiro J Exp Med Articles Nod1 is a member of family of intracellular proteins that mediate host recognition of bacterial peptidoglycan. To characterize immune responses mediated by Nod1, synthetic ligand compounds possessing enhanced ability to stimulate Nod1 were developed to study the function of Nod1. Stimulation of epithelial cells with Nod1 stimulatory molecules induced chemokines and other proinflammatory molecules that are important for innate immune responses and recruitment of acute inflammatory cells. Administration of Nod1 ligands into mice induced chemokines and recruitment of acute inflammatory cells, an activity that was abolished in Nod1-null mice. Microarray analysis revealed that Nod1 stimulation induces a restricted number of genes in intestinal epithelial cells compared with that induced by tumor necrosis factor (TNF) α. Nod1 stimulation did not induce TNFα, interleukin 12, and interferon γ, suggesting that the primary role of Nod1 is to induce the recruitment of immune cells. These results indicate that Nod1 functions as a pathogen recognition molecule to induce expression of molecules involved in the early stages of the innate immune response. The Rockefeller University Press 2006-01-23 /pmc/articles/PMC2118074/ /pubmed/16418393 http://dx.doi.org/10.1084/jem.20051229 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Masumoto, Junya
Yang, Kangkang
Varambally, Sooryanarayana
Hasegawa, Mizuho
Tomlins, Scott A.
Qiu, Su
Fujimoto, Yukari
Kawasaki, Akiko
Foster, Simon J.
Horie, Yasuo
Mak, Tak W.
Núñez, Gabriel
Chinnaiyan, Arul M.
Fukase, Koichi
Inohara, Naohiro
Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo
title Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo
title_full Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo
title_fullStr Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo
title_full_unstemmed Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo
title_short Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo
title_sort nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118074/
https://www.ncbi.nlm.nih.gov/pubmed/16418393
http://dx.doi.org/10.1084/jem.20051229
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