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Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

Death by neglect requires that CD4(+)8(+) double-positive (DP) thymocytes avoid cytokine-mediated survival signals, which is presumably why DP thymocytes normally extinguish IL-7R gene expression. We report that DP thymocytes before positive selection (preselection DP thymocytes) fail to transduce I...

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Detalles Bibliográficos
Autores principales:	Yu, Qing, Park, Jung-Hyun, Doan, Loretta L., Erman, Batu, Feigenbaum, Lionel, Singer, Alfred
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118084/ https://www.ncbi.nlm.nih.gov/pubmed/16390939 http://dx.doi.org/10.1084/jem.20051836

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