Identification of the target self-antigens in reperfusion injury

Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of n...

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Detalles Bibliográficos
Autores principales: Zhang, Ming, Alicot, Elisabeth M., Chiu, Isaac, Li, Jinan, Verna, Nicola, Vorup-Jensen, Thomas, Kessler, Benedikt, Shimaoka, Motomu, Chan, Rodney, Friend, Daniel, Mahmood, Umar, Weissleder, Ralph, Moore, Francis D., Carroll, Michael C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118091/
https://www.ncbi.nlm.nih.gov/pubmed/16390934
http://dx.doi.org/10.1084/jem.20050390
Descripción
Sumario:Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.

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