Identification of the target self-antigens in reperfusion injury

Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of n...

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Autores principales: Zhang, Ming, Alicot, Elisabeth M., Chiu, Isaac, Li, Jinan, Verna, Nicola, Vorup-Jensen, Thomas, Kessler, Benedikt, Shimaoka, Motomu, Chan, Rodney, Friend, Daniel, Mahmood, Umar, Weissleder, Ralph, Moore, Francis D., Carroll, Michael C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118091/
https://www.ncbi.nlm.nih.gov/pubmed/16390934
http://dx.doi.org/10.1084/jem.20050390
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author Zhang, Ming
Alicot, Elisabeth M.
Chiu, Isaac
Li, Jinan
Verna, Nicola
Vorup-Jensen, Thomas
Kessler, Benedikt
Shimaoka, Motomu
Chan, Rodney
Friend, Daniel
Mahmood, Umar
Weissleder, Ralph
Moore, Francis D.
Carroll, Michael C.
author_facet Zhang, Ming
Alicot, Elisabeth M.
Chiu, Isaac
Li, Jinan
Verna, Nicola
Vorup-Jensen, Thomas
Kessler, Benedikt
Shimaoka, Motomu
Chan, Rodney
Friend, Daniel
Mahmood, Umar
Weissleder, Ralph
Moore, Francis D.
Carroll, Michael C.
author_sort Zhang, Ming
collection PubMed
description Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.
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spelling pubmed-21180912007-12-13 Identification of the target self-antigens in reperfusion injury Zhang, Ming Alicot, Elisabeth M. Chiu, Isaac Li, Jinan Verna, Nicola Vorup-Jensen, Thomas Kessler, Benedikt Shimaoka, Motomu Chan, Rodney Friend, Daniel Mahmood, Umar Weissleder, Ralph Moore, Francis D. Carroll, Michael C. J Exp Med Articles Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction. The Rockefeller University Press 2006-01-23 /pmc/articles/PMC2118091/ /pubmed/16390934 http://dx.doi.org/10.1084/jem.20050390 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Zhang, Ming
Alicot, Elisabeth M.
Chiu, Isaac
Li, Jinan
Verna, Nicola
Vorup-Jensen, Thomas
Kessler, Benedikt
Shimaoka, Motomu
Chan, Rodney
Friend, Daniel
Mahmood, Umar
Weissleder, Ralph
Moore, Francis D.
Carroll, Michael C.
Identification of the target self-antigens in reperfusion injury
title Identification of the target self-antigens in reperfusion injury
title_full Identification of the target self-antigens in reperfusion injury
title_fullStr Identification of the target self-antigens in reperfusion injury
title_full_unstemmed Identification of the target self-antigens in reperfusion injury
title_short Identification of the target self-antigens in reperfusion injury
title_sort identification of the target self-antigens in reperfusion injury
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118091/
https://www.ncbi.nlm.nih.gov/pubmed/16390934
http://dx.doi.org/10.1084/jem.20050390
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