Cargando…

PD-1 is a regulator of virus-specific CD8(+) T cell survival in HIV infection

Here, we report on the expression of programmed death (PD)-1 on human virus-specific CD8(+) T cells and the effect of manipulating signaling through PD-1 on the survival, proliferation, and cytokine function of these cells. PD-1 expression was found to be low on naive CD8(+) T cells and increased on...

Descripción completa

Detalles Bibliográficos
Autores principales:	Petrovas, Constantinos, Casazza, Joseph P., Brenchley, Jason M., Price, David A., Gostick, Emma, Adams, William C., Precopio, Melissa L., Schacker, Timothy, Roederer, Mario, Douek, Daniel C., Koup, Richard A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118095/ https://www.ncbi.nlm.nih.gov/pubmed/16954372 http://dx.doi.org/10.1084/jem.20061496

Ejemplares similares

Acquisition of direct antiviral effector functions by CMV-specific CD4(+) T lymphocytes with cellular maturation
por: Casazza, Joseph P., et al.
Publicado: (2006)

High Production Rates Sustain In Vivo Levels of PD-1(high) Simian Immunodeficiency Virus-Specific CD8 T Cells in the Face of Rapid Clearance
por: Petrovas, Constantinos, et al.
Publicado: (2013)

Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses
por: Precopio, Melissa L., et al.
Publicado: (2007)

Avidity for antigen shapes clonal dominance in CD8(+) T cell populations specific for persistent DNA viruses
por: Price, David A., et al.
Publicado: (2005)

Autocrine Production of β-Chemokines Protects CMV-Specific CD4(+) T Cells from HIV Infection
por: Casazza, Joseph P., et al.
Publicado: (2009)

Public clonotype usage identifies protective Gag-specific CD8(+) T cell responses in SIV infection
por: Price, David A., et al.
Publicado: (2009)

The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses
por: Moysi, Eirini, et al.
Publicado: (2018)

Selective Loss of Early Differentiated, Highly Functional PD1(high) CD4 T Cells with HIV Progression
por: Paris, Robert M., et al.
Publicado: (2015)

Loss of Circulating CD4 T Cells with B Cell Helper Function during Chronic HIV Infection
por: Boswell, Kristin L., et al.
Publicado: (2014)

CD4(+) T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract
por: Brenchley, Jason M., et al.
Publicado: (2004)

HIV-Specific CD8(+) T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue
por: Reuter, Morgan A., et al.
Publicado: (2017)

Preferential infection and depletion of Mycobacterium tuberculosis–specific CD4 T cells after HIV-1 infection
por: Geldmacher, Christof, et al.
Publicado: (2010)

Analysis of the functional WT1-specific T-cell repertoire in healthy donors reveals a discrepancy between CD4(+) and CD8(+) memory formation
por: Schmied, Sabine, et al.
Publicado: (2015)

A CD64/FcγRI-mediated mechanism hijacks PD-1 from PD-L1/2 interaction and enhances anti-PD-1 functional recovery of exhausted T cells
por: Joo, Victor, et al.
Publicado: (2023)

Multiple modes of antigen exposure induce clonotypically diverse epitope-specific CD8(+) T cells across multiple tissues in nonhuman primates
por: Simpson, Jennifer, et al.
Publicado: (2022)

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade
por: Nakamoto, Nobuhiro, et al.
Publicado: (2009)

Jigsaw falling into place: A review and perspective of lymphoid tissue CD8+ T cells and control of HIV
por: Nguyen, Son, et al.
Publicado: (2020)

Increased differentiation associates with decreased polyfunctionality for HIV but not CMV-specific CD8+ T cell responses
por: Riou, C, et al.
Publicado: (2012)

Tuberculosis Therapy Modifies the Cytokine Profile, Maturation State, and Expression of Inhibitory Molecules on Mycobacterium tuberculosis-Specific CD4(+) T-Cells
por: Saharia, Kapil K., et al.
Publicado: (2016)

TCF-1 regulates HIV-specific CD8(+) T cell expansion capacity
por: Rutishauser, Rachel L., et al.
Publicado: (2021)

Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells
por: Vassilopoulos, Athanassios, et al.
Publicado: (2008)

HIV integration and T cell death: additional commentary
por: Cooper, Arik, et al.
Publicado: (2013)

Naïve CD8(+) T-Cells Engage a Versatile Metabolic Program Upon Activation in Humans and Differ Energetically From Memory CD8(+) T-Cells
por: Nicoli, Francesco, et al.
Publicado: (2018)

The TLR9 ligand CpG ODN 2006 is a poor adjuvant for the induction of de novo CD8(+) T-cell responses in vitro
por: Papagno, Laura, et al.
Publicado: (2020)

Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge
por: Mattapallil, Joseph J., et al.
Publicado: (2006)

CD8(+) T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold
por: Dockree, Tamsin, et al.
Publicado: (2017)

Stochastic Expansions Maintain the Clonal Stability of CD8(+) T Cell Populations Undergoing Memory Inflation Driven by Murine Cytomegalovirus
por: Smith, Corinne J., et al.
Publicado: (2020)

Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells
por: Humphreys, Ian R, et al.
Publicado: (2010)

Lower Baseline Germinal Center Activity and Preserved Th1 Immunity Are Associated With Hepatitis B Vaccine Response in Treated HIV Infection
por: Paris, Robert M., et al.
Publicado: (2017)

Tetramer Enrichment Reveals the Presence of Phenotypically Diverse Hepatitis C Virus-Specific CD8(+) T Cells in Chronic Infection
por: Nitschke, Katja, et al.
Publicado: (2014)

In Situ Characterization of Human Lymphoid Tissue Immune Cells by Multispectral Confocal Imaging and Quantitative Image Analysis; Implications for HIV Reservoir Characterization
por: Moysi, Eirini, et al.
Publicado: (2021)

Editorial: CD4+ T cells in HIV: A Friend or a Foe?
por: Govindaraj, Sakthivel, et al.
Publicado: (2023)

Reduced naïve CD8(+) T‐cell priming efficacy in elderly adults
por: Briceño, Olivia, et al.
Publicado: (2015)

P18-06. Increased HIV-specific immunity in HIV-infected individuals vaccinated with a DNA prime, rAd5 boost regimen
por: Casazza, JP, et al.
Publicado: (2009)

Acute-Phase CD8 T Cell Responses That Select for Escape Variants Are Needed to Control Live Attenuated Simian Immunodeficiency Virus
por: Harris, Max, et al.
Publicado: (2013)

Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies
por: Clement, Mathew, et al.
Publicado: (2016)

A human memory T-cell subset with stem cell-like properties
por: Gattinoni, Luca, et al.
Publicado: (2011)

Neonatal CD8 T-cell Hierarchy Is Distinct from Adults and Is Influenced by Intrinsic T cell Properties in Respiratory Syncytial Virus Infected Mice
por: Ruckwardt, Tracy J., et al.
Publicado: (2011)

S03-05 OA. A less differentiated memory phenotype of Gag-specific CD4+ T-cells during primary HIV infection associates with viral control at 12 months
por: Maenetje, PW, et al.
Publicado: (2009)

Immunodominance and functional alterations of tumor‐associated antigen‐specific CD8(+) T‐cell responses in hepatocellular carcinoma
por: Flecken, Tobias, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_47d6925n49rm17nnbnto0rcl4j