Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts

Carbon monoxide (CO), a byproduct of heme catabolism by heme oxygenase (HO), confers potent antiinflammatory effects. Here we demonstrate that CO derived from HO-1 inhibited Toll-like receptor (TLR) 2, 4, 5, and 9 signaling, but not TLR3-dependent signaling, in macrophages. Ligand-mediated receptor...

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Detalles Bibliográficos
Autores principales: Nakahira, Kiichi, Kim, Hong Pyo, Geng, Xue Hui, Nakao, Atsunori, Wang, Xue, Murase, Noriko, Drain, Peter F., Wang, Xiaomei, Sasidhar, Madhu, Nabel, Elizabeth G., Takahashi, Toru, Lukacs, Nicholas W., Ryter, Stefan W., Morita, Kiyoshi, Choi, Augustine M.K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118097/
https://www.ncbi.nlm.nih.gov/pubmed/17000866
http://dx.doi.org/10.1084/jem.20060845

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