Giving blood: a new role for CD40 in tumorigenesis

CD40 was initially identified as a receptor expressed by B cells that is crucial for inducing an effective adaptive immune response. CD40 was subsequently shown to be expressed by endothelial cells and to promote angiogenesis. New data now show that in tumor-prone transgenic mice, CD40-mediated neov...

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Detalles Bibliográficos
Autores principales: Bergmann, Stephan, Pandolfi, Pier Paolo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118122/
https://www.ncbi.nlm.nih.gov/pubmed/17043147
http://dx.doi.org/10.1084/jem.20061754
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author Bergmann, Stephan
Pandolfi, Pier Paolo
author_facet Bergmann, Stephan
Pandolfi, Pier Paolo
author_sort Bergmann, Stephan
collection PubMed
description CD40 was initially identified as a receptor expressed by B cells that is crucial for inducing an effective adaptive immune response. CD40 was subsequently shown to be expressed by endothelial cells and to promote angiogenesis. New data now show that in tumor-prone transgenic mice, CD40-mediated neovascularization is essential for early stage tumorigenicity. This suggests, at least in this mouse model, that CD40 has an important role in the angiogenic process that is coupled to carcinogenesis, a finding that could lead to novel therapeutic opportunities.
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spelling pubmed-21181222007-12-13 Giving blood: a new role for CD40 in tumorigenesis Bergmann, Stephan Pandolfi, Pier Paolo J Exp Med Commentaries CD40 was initially identified as a receptor expressed by B cells that is crucial for inducing an effective adaptive immune response. CD40 was subsequently shown to be expressed by endothelial cells and to promote angiogenesis. New data now show that in tumor-prone transgenic mice, CD40-mediated neovascularization is essential for early stage tumorigenicity. This suggests, at least in this mouse model, that CD40 has an important role in the angiogenic process that is coupled to carcinogenesis, a finding that could lead to novel therapeutic opportunities. The Rockefeller University Press 2006-10-30 /pmc/articles/PMC2118122/ /pubmed/17043147 http://dx.doi.org/10.1084/jem.20061754 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Bergmann, Stephan
Pandolfi, Pier Paolo
Giving blood: a new role for CD40 in tumorigenesis
title Giving blood: a new role for CD40 in tumorigenesis
title_full Giving blood: a new role for CD40 in tumorigenesis
title_fullStr Giving blood: a new role for CD40 in tumorigenesis
title_full_unstemmed Giving blood: a new role for CD40 in tumorigenesis
title_short Giving blood: a new role for CD40 in tumorigenesis
title_sort giving blood: a new role for cd40 in tumorigenesis
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118122/
https://www.ncbi.nlm.nih.gov/pubmed/17043147
http://dx.doi.org/10.1084/jem.20061754
work_keys_str_mv AT bergmannstephan givingbloodanewroleforcd40intumorigenesis
AT pandolfipierpaolo givingbloodanewroleforcd40intumorigenesis

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