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Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis

Follicular lymphoma is one of the most common adult lymphoma, and remains virtually incurable despite its relatively indolent nature. t(14;18)(q32;q21) translocation, the genetic hallmark and early initiating event of follicular lymphoma (FL) pathogenesis, is also present at low frequency in the per...

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Autores principales: Roulland, Sandrine, Navarro, Jean-Marc, Grenot, Pierre, Milili, Michèle, Agopian, Julie, Montpellier, Bertrand, Gauduchon, Pascal, Lebailly, Pierre, Schiff, Claudine, Nadel, Bertrand
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118129/
https://www.ncbi.nlm.nih.gov/pubmed/17043145
http://dx.doi.org/10.1084/jem.20061292
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author Roulland, Sandrine
Navarro, Jean-Marc
Grenot, Pierre
Milili, Michèle
Agopian, Julie
Montpellier, Bertrand
Gauduchon, Pascal
Lebailly, Pierre
Schiff, Claudine
Nadel, Bertrand
author_facet Roulland, Sandrine
Navarro, Jean-Marc
Grenot, Pierre
Milili, Michèle
Agopian, Julie
Montpellier, Bertrand
Gauduchon, Pascal
Lebailly, Pierre
Schiff, Claudine
Nadel, Bertrand
author_sort Roulland, Sandrine
collection PubMed
description Follicular lymphoma is one of the most common adult lymphoma, and remains virtually incurable despite its relatively indolent nature. t(14;18)(q32;q21) translocation, the genetic hallmark and early initiating event of follicular lymphoma (FL) pathogenesis, is also present at low frequency in the peripheral blood of healthy individuals. It has long been assumed that in healthy individuals t(14;18) is carried by circulating quiescent naive B cells, where its oncogenic potential would be restrained. Here, we question this current view and demonstrate that in healthy individuals, t(14;18) is actually carried by an expanding population of atypical B cells issued from germinal centers, displaying genotypic and phenotypic features of FL, and prone to constitute potent premalignant FL niches. These findings strongly impact both on the current understanding of disease progression and on the proper handling of t(14;18) frequency in blood as a potential early biomarker for lymphoma.
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spelling pubmed-21181292007-12-13 Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis Roulland, Sandrine Navarro, Jean-Marc Grenot, Pierre Milili, Michèle Agopian, Julie Montpellier, Bertrand Gauduchon, Pascal Lebailly, Pierre Schiff, Claudine Nadel, Bertrand J Exp Med Brief Definitive Reports Follicular lymphoma is one of the most common adult lymphoma, and remains virtually incurable despite its relatively indolent nature. t(14;18)(q32;q21) translocation, the genetic hallmark and early initiating event of follicular lymphoma (FL) pathogenesis, is also present at low frequency in the peripheral blood of healthy individuals. It has long been assumed that in healthy individuals t(14;18) is carried by circulating quiescent naive B cells, where its oncogenic potential would be restrained. Here, we question this current view and demonstrate that in healthy individuals, t(14;18) is actually carried by an expanding population of atypical B cells issued from germinal centers, displaying genotypic and phenotypic features of FL, and prone to constitute potent premalignant FL niches. These findings strongly impact both on the current understanding of disease progression and on the proper handling of t(14;18) frequency in blood as a potential early biomarker for lymphoma. The Rockefeller University Press 2006-10-30 /pmc/articles/PMC2118129/ /pubmed/17043145 http://dx.doi.org/10.1084/jem.20061292 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Roulland, Sandrine
Navarro, Jean-Marc
Grenot, Pierre
Milili, Michèle
Agopian, Julie
Montpellier, Bertrand
Gauduchon, Pascal
Lebailly, Pierre
Schiff, Claudine
Nadel, Bertrand
Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
title Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
title_full Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
title_fullStr Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
title_full_unstemmed Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
title_short Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
title_sort follicular lymphoma-like b cells in healthy individuals: a novel intermediate step in early lymphomagenesis
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118129/
https://www.ncbi.nlm.nih.gov/pubmed/17043145
http://dx.doi.org/10.1084/jem.20061292
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