Cargando…
Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenecity of human platelets
Tissue factor (TF) is an essential cofactor for the activation of blood coagulation in vivo. We now report that quiescent human platelets express TF pre-mRNA and, in response to activation, splice this intronic-rich message into mature mRNA. Splicing of TF pre-mRNA is associated with increased TF pr...
Autores principales: | Schwertz, Hansjörg, Tolley, Neal D., Foulks, Jason M., Denis, Melvin M., Risenmay, Ben W., Buerke, Michael, Tilley, Rachel E., Rondina, Matthew T., Harris, Estelle M., Kraiss, Larry W., Mackman, Nigel, Zimmerman, Guy A., Weyrich, Andrew S. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2006
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118136/ https://www.ncbi.nlm.nih.gov/pubmed/17060476 http://dx.doi.org/10.1084/jem.20061302 |
Ejemplares similares
-
2098: Endogenous reverse transcriptase (LINE-1) in human platelets regulates cell morphology and protein synthetic events
por: Schwertz, Hansjorg, et al.
Publicado: (2018) -
Evaluation of the thrombogenecity of microvascular prosthesis by in vivo microscopy.
por: Kim, Y. B., et al.
Publicado: (1994) -
Do platelets LINE up for aging?
por: Schwertz, Hansjörg, et al.
Publicado: (2018) -
Platelet precursors display bipolar behavior
por: Schwertz, Hansjörg, et al.
Publicado: (2010) -
Platelet-Monocyte Aggregates and C-Reactive Protein are Associated with VTE in Older Surgical Patients
por: Shih, Lauren, et al.
Publicado: (2016)