IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis

Aberrant cytokine expression has been proposed as an underlying cause of psoriasis, although it is unclear which cytokines play critical roles. Interleukin (IL)-23 is expressed in human psoriasis and may be a master regulator cytokine. Direct intradermal administration of IL-23 in mouse skin, but no...

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Detalles Bibliográficos
Autores principales: Chan, Jason R., Blumenschein, Wendy, Murphy, Erin, Diveu, Caroline, Wiekowski, Maria, Abbondanzo, Susan, Lucian, Linda, Geissler, Richard, Brodie, Scott, Kimball, Alexa B., Gorman, Daniel M., Smith, Kathleen, de Waal Malefyt, Rene, Kastelein, Robert A., McClanahan, Terrill K., Bowman, Edward P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118145/
https://www.ncbi.nlm.nih.gov/pubmed/17074928
http://dx.doi.org/10.1084/jem.20060244

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