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Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

Phosphodiesterase-5 (PDE5) inhibitors (sildenafil, tadalafil, and vardenafil) are agents currently in clinical use for nonmalignant conditions. We report the use of PDE5 inhibitors as modulators of the antitumor immune response. In several mouse tumor models, PDE5 inhibition reverses tumor-induced i...

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Detalles Bibliográficos
Autores principales:	Serafini, Paolo, Meckel, Kristen, Kelso, Michael, Noonan, Kimberly, Califano, Joseph, Koch, Wayne, Dolcetti, Luigi, Bronte, Vincenzo, Borrello, Ivan
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118163/ https://www.ncbi.nlm.nih.gov/pubmed/17101732 http://dx.doi.org/10.1084/jem.20061104

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