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Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men

In this study, we explored dermal dendritic cell (DC) homeostasis in mice and humans both in the steady state and after hematopoietic cell transplantation. We discovered that dermal DCs proliferate in situ in mice and human quiescent dermis. In parabiotic mice with separate organs but shared blood c...

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Autores principales: Bogunovic, Milena, Ginhoux, Florent, Wagers, Amy, Loubeau, Martine, Isola, Luis M., Lubrano, Lauren, Najfeld, Vesna, Phelps, Robert G., Grosskreutz, Celia, Scigliano, Eilleen, Frenette, Paul S., Merad, Miriam
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118165/
https://www.ncbi.nlm.nih.gov/pubmed/17116734
http://dx.doi.org/10.1084/jem.20060667
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author Bogunovic, Milena
Ginhoux, Florent
Wagers, Amy
Loubeau, Martine
Isola, Luis M.
Lubrano, Lauren
Najfeld, Vesna
Phelps, Robert G.
Grosskreutz, Celia
Scigliano, Eilleen
Frenette, Paul S.
Merad, Miriam
author_facet Bogunovic, Milena
Ginhoux, Florent
Wagers, Amy
Loubeau, Martine
Isola, Luis M.
Lubrano, Lauren
Najfeld, Vesna
Phelps, Robert G.
Grosskreutz, Celia
Scigliano, Eilleen
Frenette, Paul S.
Merad, Miriam
author_sort Bogunovic, Milena
collection PubMed
description In this study, we explored dermal dendritic cell (DC) homeostasis in mice and humans both in the steady state and after hematopoietic cell transplantation. We discovered that dermal DCs proliferate in situ in mice and human quiescent dermis. In parabiotic mice with separate organs but shared blood circulation, the majority of dermal DCs failed to be replaced by circulating precursors for >6 mo. In lethally irradiated mice injected with donor congenic bone marrow (BM) cells, a subset of recipient DCs remained in the dermis and proliferated locally throughout life. Consistent with these findings, a large proportion of recipient dermal DCs remained in patients' skin after allogeneic hematopoietic cell transplantation, despite complete donor BM chimerism. Collectively, our results oppose the traditional view that DCs are nondividing terminally differentiated cells maintained by circulating precursors and support the new paradigm that tissue DCs have local proliferative properties that control their homeostasis in the steady state. Given the role of residual host tissue DCs in transplant immune reactions, these results suggest that dermal DC homeostasis may contribute to the development of cutaneous graft-versus-host disease in clinical transplantation.
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spelling pubmed-21181652007-12-13 Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men Bogunovic, Milena Ginhoux, Florent Wagers, Amy Loubeau, Martine Isola, Luis M. Lubrano, Lauren Najfeld, Vesna Phelps, Robert G. Grosskreutz, Celia Scigliano, Eilleen Frenette, Paul S. Merad, Miriam J Exp Med Articles In this study, we explored dermal dendritic cell (DC) homeostasis in mice and humans both in the steady state and after hematopoietic cell transplantation. We discovered that dermal DCs proliferate in situ in mice and human quiescent dermis. In parabiotic mice with separate organs but shared blood circulation, the majority of dermal DCs failed to be replaced by circulating precursors for >6 mo. In lethally irradiated mice injected with donor congenic bone marrow (BM) cells, a subset of recipient DCs remained in the dermis and proliferated locally throughout life. Consistent with these findings, a large proportion of recipient dermal DCs remained in patients' skin after allogeneic hematopoietic cell transplantation, despite complete donor BM chimerism. Collectively, our results oppose the traditional view that DCs are nondividing terminally differentiated cells maintained by circulating precursors and support the new paradigm that tissue DCs have local proliferative properties that control their homeostasis in the steady state. Given the role of residual host tissue DCs in transplant immune reactions, these results suggest that dermal DC homeostasis may contribute to the development of cutaneous graft-versus-host disease in clinical transplantation. The Rockefeller University Press 2006-11-27 /pmc/articles/PMC2118165/ /pubmed/17116734 http://dx.doi.org/10.1084/jem.20060667 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Bogunovic, Milena
Ginhoux, Florent
Wagers, Amy
Loubeau, Martine
Isola, Luis M.
Lubrano, Lauren
Najfeld, Vesna
Phelps, Robert G.
Grosskreutz, Celia
Scigliano, Eilleen
Frenette, Paul S.
Merad, Miriam
Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men
title Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men
title_full Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men
title_fullStr Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men
title_full_unstemmed Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men
title_short Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men
title_sort identification of a radio-resistant and cycling dermal dendritic cell population in mice and men
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118165/
https://www.ncbi.nlm.nih.gov/pubmed/17116734
http://dx.doi.org/10.1084/jem.20060667
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