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Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men
In this study, we explored dermal dendritic cell (DC) homeostasis in mice and humans both in the steady state and after hematopoietic cell transplantation. We discovered that dermal DCs proliferate in situ in mice and human quiescent dermis. In parabiotic mice with separate organs but shared blood c...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118165/ https://www.ncbi.nlm.nih.gov/pubmed/17116734 http://dx.doi.org/10.1084/jem.20060667 |
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author | Bogunovic, Milena Ginhoux, Florent Wagers, Amy Loubeau, Martine Isola, Luis M. Lubrano, Lauren Najfeld, Vesna Phelps, Robert G. Grosskreutz, Celia Scigliano, Eilleen Frenette, Paul S. Merad, Miriam |
author_facet | Bogunovic, Milena Ginhoux, Florent Wagers, Amy Loubeau, Martine Isola, Luis M. Lubrano, Lauren Najfeld, Vesna Phelps, Robert G. Grosskreutz, Celia Scigliano, Eilleen Frenette, Paul S. Merad, Miriam |
author_sort | Bogunovic, Milena |
collection | PubMed |
description | In this study, we explored dermal dendritic cell (DC) homeostasis in mice and humans both in the steady state and after hematopoietic cell transplantation. We discovered that dermal DCs proliferate in situ in mice and human quiescent dermis. In parabiotic mice with separate organs but shared blood circulation, the majority of dermal DCs failed to be replaced by circulating precursors for >6 mo. In lethally irradiated mice injected with donor congenic bone marrow (BM) cells, a subset of recipient DCs remained in the dermis and proliferated locally throughout life. Consistent with these findings, a large proportion of recipient dermal DCs remained in patients' skin after allogeneic hematopoietic cell transplantation, despite complete donor BM chimerism. Collectively, our results oppose the traditional view that DCs are nondividing terminally differentiated cells maintained by circulating precursors and support the new paradigm that tissue DCs have local proliferative properties that control their homeostasis in the steady state. Given the role of residual host tissue DCs in transplant immune reactions, these results suggest that dermal DC homeostasis may contribute to the development of cutaneous graft-versus-host disease in clinical transplantation. |
format | Text |
id | pubmed-2118165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21181652007-12-13 Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men Bogunovic, Milena Ginhoux, Florent Wagers, Amy Loubeau, Martine Isola, Luis M. Lubrano, Lauren Najfeld, Vesna Phelps, Robert G. Grosskreutz, Celia Scigliano, Eilleen Frenette, Paul S. Merad, Miriam J Exp Med Articles In this study, we explored dermal dendritic cell (DC) homeostasis in mice and humans both in the steady state and after hematopoietic cell transplantation. We discovered that dermal DCs proliferate in situ in mice and human quiescent dermis. In parabiotic mice with separate organs but shared blood circulation, the majority of dermal DCs failed to be replaced by circulating precursors for >6 mo. In lethally irradiated mice injected with donor congenic bone marrow (BM) cells, a subset of recipient DCs remained in the dermis and proliferated locally throughout life. Consistent with these findings, a large proportion of recipient dermal DCs remained in patients' skin after allogeneic hematopoietic cell transplantation, despite complete donor BM chimerism. Collectively, our results oppose the traditional view that DCs are nondividing terminally differentiated cells maintained by circulating precursors and support the new paradigm that tissue DCs have local proliferative properties that control their homeostasis in the steady state. Given the role of residual host tissue DCs in transplant immune reactions, these results suggest that dermal DC homeostasis may contribute to the development of cutaneous graft-versus-host disease in clinical transplantation. The Rockefeller University Press 2006-11-27 /pmc/articles/PMC2118165/ /pubmed/17116734 http://dx.doi.org/10.1084/jem.20060667 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Bogunovic, Milena Ginhoux, Florent Wagers, Amy Loubeau, Martine Isola, Luis M. Lubrano, Lauren Najfeld, Vesna Phelps, Robert G. Grosskreutz, Celia Scigliano, Eilleen Frenette, Paul S. Merad, Miriam Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men |
title | Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men |
title_full | Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men |
title_fullStr | Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men |
title_full_unstemmed | Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men |
title_short | Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men |
title_sort | identification of a radio-resistant and cycling dermal dendritic cell population in mice and men |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118165/ https://www.ncbi.nlm.nih.gov/pubmed/17116734 http://dx.doi.org/10.1084/jem.20060667 |
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