Deregulated Syk inhibits differentiation and induces growth factor–independent proliferation of pre–B cells

The nonreceptor protein spleen tyrosine kinase (Syk) is a key mediator of signal transduction in a variety of cell types, including B lymphocytes. We show that deregulated Syk activity allows growth factor–independent proliferation and transforms bone marrow–derived pre–B cells that are then able to...

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Detalles Bibliográficos
Autores principales: Wossning, Thomas, Herzog, Sebastian, Köhler, Fabian, Meixlsperger, Sonja, Kulathu, Yogesh, Mittler, Gerhard, Abe, Akihiro, Fuchs, Uta, Borkhardt, Arndt, Jumaa, Hassan
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118175/
https://www.ncbi.nlm.nih.gov/pubmed/17130299
http://dx.doi.org/10.1084/jem.20060967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118175/
https://www.ncbi.nlm.nih.gov/pubmed/17130299
http://dx.doi.org/10.1084/jem.20060967

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