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Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

Somatic hypermutation of Ig genes enables B cells of the germinal center to generate high-affinity immunoglobulin variants. Key intermediates in somatic hypermutation are deoxyuridine lesions, introduced by activation-induced cytidine deaminase. These lesions can be processed further to abasic sites...

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Detalles Bibliográficos
Autores principales:	Jansen, Jacob G., Langerak, Petra, Tsaalbi-Shtylik, Anastasia, van den Berk, Paul, Jacobs, Heinz, de Wind, Niels
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Brief Definitive Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118202/ https://www.ncbi.nlm.nih.gov/pubmed/16476771 http://dx.doi.org/10.1084/jem.20052227

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