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Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin

3-hydroxy-3-methylglutaryl–coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases. Blockade of this enzyme by atorvastatin (AT) inhibits the destructi...

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Detalles Bibliográficos
Autores principales:	Dunn, Shannon E., Youssef, Sawsan, Goldstein, Matthew J., Prod'homme, Thomas, Weber, Martin S., Zamvil, Scott S., Steinman, Lawrence
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118212/ https://www.ncbi.nlm.nih.gov/pubmed/16476765 http://dx.doi.org/10.1084/jem.20051129

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