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Prostacyclin-IP signaling and prostaglandin E(2)-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis
Prostaglandin (PG)I(2) (prostacyclin [PGI]) and PGE(2) are abundantly present in the synovial fluid of rheumatoid arthritis (RA) patients. Although the role of PGE(2) in RA has been well studied, how much PGI(2) contributes to RA is little known. To examine this issue, we backcrossed mice lacking th...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118213/ https://www.ncbi.nlm.nih.gov/pubmed/16446378 http://dx.doi.org/10.1084/jem.20051310 |