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Antibody isotype-specific engagement of Fcγ receptors regulates B lymphocyte depletion during CD20 immunotherapy

CD20 monoclonal antibody (mAb) immunotherapy is effective for lymphoma and autoimmune disease. In a mouse model of immunotherapy using mouse anti–mouse CD20 mAbs, the innate monocyte network depletes B cells through immunoglobulin (Ig)G Fc receptor (FcγR)-dependent pathways with a hierarchy of IgG2a...

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Detalles Bibliográficos
Autores principales:	Hamaguchi, Yasuhito, Xiu, Yan, Komura, Kazuhiro, Nimmerjahn, Falk, Tedder, Thomas F.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118227/ https://www.ncbi.nlm.nih.gov/pubmed/16520392 http://dx.doi.org/10.1084/jem.20052283

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