Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis

Formation of fibrin is critical for limiting blood loss at a site of blood vessel injury (hemostasis), but may also contribute to vascular thrombosis. Hereditary deficiency of factor XII (FXII), the protease that triggers the intrinsic pathway of coagulation in vitro, is not associated with spontane...

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Detalles Bibliográficos
Autores principales: Kleinschnitz, Christoph, Stoll, Guido, Bendszus, Martin, Schuh, Kai, Pauer, Hans-Ulrich, Burfeind, Peter, Renné, Christoph, Gailani, David, Nieswandt, Bernhard, Renné, Thomas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118228/
https://www.ncbi.nlm.nih.gov/pubmed/16533887
http://dx.doi.org/10.1084/jem.20052458

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