In vivo sites and cellular mechanisms of T reg cell–mediated suppression

Regulatory CD4 T (T reg) cells control immune responses to self-antigens and pathogens. However, where T reg cells act to curtail effector T cells in vivo and what stage of effector T cell activation or differentiation is targeted by T reg cells remain unknown. Furthermore, a requirement for direct...

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Detalles Bibliográficos
Autores principales: Rudensky, Alexander Y., Campbell, Daniel J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118229/
https://www.ncbi.nlm.nih.gov/pubmed/16533888
http://dx.doi.org/10.1084/jem.20060214
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author Rudensky, Alexander Y.
Campbell, Daniel J.
author_facet Rudensky, Alexander Y.
Campbell, Daniel J.
author_sort Rudensky, Alexander Y.
collection PubMed
description Regulatory CD4 T (T reg) cells control immune responses to self-antigens and pathogens. However, where T reg cells act to curtail effector T cells in vivo and what stage of effector T cell activation or differentiation is targeted by T reg cells remain unknown. Furthermore, a requirement for direct effector T cell–T reg cell contact in vivo has not been ascertained. Varying answers to these important questions have been provided by several new studies.
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spelling pubmed-21182292007-12-13 In vivo sites and cellular mechanisms of T reg cell–mediated suppression Rudensky, Alexander Y. Campbell, Daniel J. J Exp Med Commentaries Regulatory CD4 T (T reg) cells control immune responses to self-antigens and pathogens. However, where T reg cells act to curtail effector T cells in vivo and what stage of effector T cell activation or differentiation is targeted by T reg cells remain unknown. Furthermore, a requirement for direct effector T cell–T reg cell contact in vivo has not been ascertained. Varying answers to these important questions have been provided by several new studies. The Rockefeller University Press 2006-03-20 /pmc/articles/PMC2118229/ /pubmed/16533888 http://dx.doi.org/10.1084/jem.20060214 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Rudensky, Alexander Y.
Campbell, Daniel J.
In vivo sites and cellular mechanisms of T reg cell–mediated suppression
title In vivo sites and cellular mechanisms of T reg cell–mediated suppression
title_full In vivo sites and cellular mechanisms of T reg cell–mediated suppression
title_fullStr In vivo sites and cellular mechanisms of T reg cell–mediated suppression
title_full_unstemmed In vivo sites and cellular mechanisms of T reg cell–mediated suppression
title_short In vivo sites and cellular mechanisms of T reg cell–mediated suppression
title_sort in vivo sites and cellular mechanisms of t reg cell–mediated suppression
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118229/
https://www.ncbi.nlm.nih.gov/pubmed/16533888
http://dx.doi.org/10.1084/jem.20060214
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AT campbelldanielj invivositesandcellularmechanismsoftregcellmediatedsuppression

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