TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE

Loss of tolerance in systemic lupus erythematosus (SLE) leads to the generation of autoantibodies, which accumulate in end-organs where they induce disease. Here we show that immunoglobulin (Ig)G2a and 2b autoantibodies are the pathogenic isotypes by recruiting FcγRIV expressing macrophages. Class s...

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Detalles Bibliográficos
Autores principales: Ehlers, Marc, Fukuyama, Hidehiro, McGaha, Tracy L., Aderem, Alan, Ravetch, Jeffrey V.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118244/
https://www.ncbi.nlm.nih.gov/pubmed/16492804
http://dx.doi.org/10.1084/jem.20052438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118244/
https://www.ncbi.nlm.nih.gov/pubmed/16492804
http://dx.doi.org/10.1084/jem.20052438

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