Mesenteric lymph nodes at the center of immune anatomy

The surface of the intestinal mucosa is constantly assaulted by food antigens and enormous numbers of commensal microbes and their products, which are sampled by dendritic cells (DCs). Recent work shows that the mesenteric lymph nodes (MLNs) are the key site for tolerance induction to food proteins...

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Detalles Bibliográficos
Autores principales: Macpherson, Andrew J., Smith, Karen
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118258/
https://www.ncbi.nlm.nih.gov/pubmed/16533891
http://dx.doi.org/10.1084/jem.20060227
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author Macpherson, Andrew J.
Smith, Karen
author_facet Macpherson, Andrew J.
Smith, Karen
author_sort Macpherson, Andrew J.
collection PubMed
description The surface of the intestinal mucosa is constantly assaulted by food antigens and enormous numbers of commensal microbes and their products, which are sampled by dendritic cells (DCs). Recent work shows that the mesenteric lymph nodes (MLNs) are the key site for tolerance induction to food proteins and that they also act as a firewall to prevent live commensal intestinal bacteria from penetrating the systemic immune system.
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spelling pubmed-21182582007-12-13 Mesenteric lymph nodes at the center of immune anatomy Macpherson, Andrew J. Smith, Karen J Exp Med Commentaries The surface of the intestinal mucosa is constantly assaulted by food antigens and enormous numbers of commensal microbes and their products, which are sampled by dendritic cells (DCs). Recent work shows that the mesenteric lymph nodes (MLNs) are the key site for tolerance induction to food proteins and that they also act as a firewall to prevent live commensal intestinal bacteria from penetrating the systemic immune system. The Rockefeller University Press 2006-03-20 /pmc/articles/PMC2118258/ /pubmed/16533891 http://dx.doi.org/10.1084/jem.20060227 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Macpherson, Andrew J.
Smith, Karen
Mesenteric lymph nodes at the center of immune anatomy
title Mesenteric lymph nodes at the center of immune anatomy
title_full Mesenteric lymph nodes at the center of immune anatomy
title_fullStr Mesenteric lymph nodes at the center of immune anatomy
title_full_unstemmed Mesenteric lymph nodes at the center of immune anatomy
title_short Mesenteric lymph nodes at the center of immune anatomy
title_sort mesenteric lymph nodes at the center of immune anatomy
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118258/
https://www.ncbi.nlm.nih.gov/pubmed/16533891
http://dx.doi.org/10.1084/jem.20060227
work_keys_str_mv AT macphersonandrewj mesentericlymphnodesatthecenterofimmuneanatomy
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