Virus-specific CD4(+) T cells: ready for direct attack

CD4(+) T cells are classically thought to orchestrate adaptive immune responses. But recent studies demonstrate that they can also kill infected cells directly. A new paper shows that highly efficient processing of Epstein Barr virus (EBV) glycoproteins for presentation on MHC class II makes virus-t...

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Detalles Bibliográficos
Autores principales: Heller, Kevin N., Gurer, Cagan, Münz, Christian
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118265/
https://www.ncbi.nlm.nih.gov/pubmed/16549599
http://dx.doi.org/10.1084/jem.20060215
Descripción
Sumario:CD4(+) T cells are classically thought to orchestrate adaptive immune responses. But recent studies demonstrate that they can also kill infected cells directly. A new paper shows that highly efficient processing of Epstein Barr virus (EBV) glycoproteins for presentation on MHC class II makes virus-transformed B cells susceptible to lysis by CD4(+) T cells. Thus, antiviral vaccines should aim to stimulate both helper and cytolytic CD4(+) T cells.

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