Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1

Suppressor of cytokine signaling (SOCS)3 is a major negative feedback regulator of signal transducer and activator of transcription (STAT)3-activating cytokines. Transgenic mouse studies indicate that high levels of SOCS3 in T cells result in type 2 T helper cell (Th2) skewing and lead to hypersensi...

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Detalles Bibliográficos
Autores principales: Kinjyo, Ichiko, Inoue, Hiromasa, Hamano, Shinjiro, Fukuyama, Satoru, Yoshimura, Takeru, Koga, Keiko, Takaki, Hiromi, Himeno, Kunisuke, Takaesu, Giichi, Kobayashi, Takashi, Yoshimura, Akihiko
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118269/
https://www.ncbi.nlm.nih.gov/pubmed/16606674
http://dx.doi.org/10.1084/jem.20052333

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