Cargando…
Tissue expression of PD-L1 mediates peripheral T cell tolerance
Programmed death 1 (PD-1), an inhibitory receptor expressed on activated lymphocytes, regulates tolerance and autoimmunity. PD-1 has two ligands: PD-1 ligand 1 (PD-L1), which is expressed broadly on hematopoietic and parenchymal cells, including pancreatic islet cells; and PD-L2, which is restricted...
Autores principales: | Keir, Mary E., Liang, Spencer C., Guleria, Indira, Latchman, Yvette E., Qipo, Andi, Albacker, Lee A., Koulmanda, Maria, Freeman, Gordon J., Sayegh, Mohamed H., Sharpe, Arlene H. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2006
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118286/ https://www.ncbi.nlm.nih.gov/pubmed/16606670 http://dx.doi.org/10.1084/jem.20051776 |
Ejemplares similares
-
Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade
por: Freeman, Gordon J., et al.
Publicado: (2006) -
RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance
por: Xiao, Yanping, et al.
Publicado: (2014) -
The Role of TNF-α in Mice with Type 1- and 2- Diabetes
por: Koulmanda, Maria, et al.
Publicado: (2012) -
An HPV-E6/E7 immunotherapy plus PD-1 checkpoint inhibition results in tumor regression and reduction in PD-L1 expression
por: Rice, Adrian E, et al.
Publicado: (2015) -
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1–PD-L1 pathway
por: Fife, Brian T., et al.
Publicado: (2006)