Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!

In the dark ages of T cell biology, we considered two fates for differentiated CD4(+) T cells: T helper (Th)1 and Th2 cells. Now we know that the reality is much more complex and interesting. The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17–related cytokine IL...

Descripción completa

Detalles Bibliográficos
Autores principales: Tato, Cristina M., Laurence, Arian, O'Shea, John J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118289/
https://www.ncbi.nlm.nih.gov/pubmed/16606679
http://dx.doi.org/10.1084/jem.20060522
Descripción
Sumario:In the dark ages of T cell biology, we considered two fates for differentiated CD4(+) T cells: T helper (Th)1 and Th2 cells. Now we know that the reality is much more complex and interesting. The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17–related cytokine IL-25 is essential for Th2 responses in two infectious disease models.

Ejemplares similares