Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!

In the dark ages of T cell biology, we considered two fates for differentiated CD4(+) T cells: T helper (Th)1 and Th2 cells. Now we know that the reality is much more complex and interesting. The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17–related cytokine IL...

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Detalles Bibliográficos
Autores principales: Tato, Cristina M., Laurence, Arian, O'Shea, John J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118289/
https://www.ncbi.nlm.nih.gov/pubmed/16606679
http://dx.doi.org/10.1084/jem.20060522
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author Tato, Cristina M.
Laurence, Arian
O'Shea, John J.
author_facet Tato, Cristina M.
Laurence, Arian
O'Shea, John J.
author_sort Tato, Cristina M.
collection PubMed
description In the dark ages of T cell biology, we considered two fates for differentiated CD4(+) T cells: T helper (Th)1 and Th2 cells. Now we know that the reality is much more complex and interesting. The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17–related cytokine IL-25 is essential for Th2 responses in two infectious disease models.
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spelling pubmed-21182892007-12-13 Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi! Tato, Cristina M. Laurence, Arian O'Shea, John J. J Exp Med Commentaries In the dark ages of T cell biology, we considered two fates for differentiated CD4(+) T cells: T helper (Th)1 and Th2 cells. Now we know that the reality is much more complex and interesting. The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17–related cytokine IL-25 is essential for Th2 responses in two infectious disease models. The Rockefeller University Press 2006-04-17 /pmc/articles/PMC2118289/ /pubmed/16606679 http://dx.doi.org/10.1084/jem.20060522 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Tato, Cristina M.
Laurence, Arian
O'Shea, John J.
Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!
title Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!
title_full Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!
title_fullStr Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!
title_full_unstemmed Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!
title_short Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!
title_sort helper t cell differentiation enters a new era: le roi est mort; vive le roi!
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118289/
https://www.ncbi.nlm.nih.gov/pubmed/16606679
http://dx.doi.org/10.1084/jem.20060522
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AT laurencearian helpertcelldifferentiationentersaneweraleroiestmortviveleroi
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