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CD4(+) T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells

We explored the relationship between the time of naive CD4(+) T cell exposure to antigen in the primary immune response and the quality of the memory cells produced. Naive CD4(+) T cells that migrated into the skin-draining lymph nodes after subcutaneous antigen injection accounted for about half of...

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Detalles Bibliográficos
Autores principales: Catron, Drew M., Rusch, Lori K., Hataye, Jason, Itano, Andrea A., Jenkins, Marc K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118291/
https://www.ncbi.nlm.nih.gov/pubmed/16567390
http://dx.doi.org/10.1084/jem.20051954
Descripción
Sumario:We explored the relationship between the time of naive CD4(+) T cell exposure to antigen in the primary immune response and the quality of the memory cells produced. Naive CD4(+) T cells that migrated into the skin-draining lymph nodes after subcutaneous antigen injection accounted for about half of the antigen-specific population present at the peak of clonal expansion. These late-arriving T cells divided less and more retained the central–memory marker CD62L than the T cells that resided in the draining lymph nodes at the time of antigen injection. The fewer cell divisions were related to competition with resident T cells that expanded earlier in the response and a reduction in the number of dendritic cells displaying peptide–major histocompatibility complex (MHC) II complexes at later times after antigen injection. The progeny of late-arriving T cells possessed the phenotype of central–memory cells, and proliferated more extensively during the secondary response than the progeny of the resident T cells. The results suggest that late arrival into lymph nodes and exposure to antigen-presenting cells displaying lower numbers of peptide–MHC II complexes in the presence of competing T cells ensures that some antigen-specific CD4(+) T cells divide less in the primary response and become central–memory cells.