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CD4(+) T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells

We explored the relationship between the time of naive CD4(+) T cell exposure to antigen in the primary immune response and the quality of the memory cells produced. Naive CD4(+) T cells that migrated into the skin-draining lymph nodes after subcutaneous antigen injection accounted for about half of...

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Detalles Bibliográficos
Autores principales: Catron, Drew M., Rusch, Lori K., Hataye, Jason, Itano, Andrea A., Jenkins, Marc K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118291/
https://www.ncbi.nlm.nih.gov/pubmed/16567390
http://dx.doi.org/10.1084/jem.20051954
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author Catron, Drew M.
Rusch, Lori K.
Hataye, Jason
Itano, Andrea A.
Jenkins, Marc K.
author_facet Catron, Drew M.
Rusch, Lori K.
Hataye, Jason
Itano, Andrea A.
Jenkins, Marc K.
author_sort Catron, Drew M.
collection PubMed
description We explored the relationship between the time of naive CD4(+) T cell exposure to antigen in the primary immune response and the quality of the memory cells produced. Naive CD4(+) T cells that migrated into the skin-draining lymph nodes after subcutaneous antigen injection accounted for about half of the antigen-specific population present at the peak of clonal expansion. These late-arriving T cells divided less and more retained the central–memory marker CD62L than the T cells that resided in the draining lymph nodes at the time of antigen injection. The fewer cell divisions were related to competition with resident T cells that expanded earlier in the response and a reduction in the number of dendritic cells displaying peptide–major histocompatibility complex (MHC) II complexes at later times after antigen injection. The progeny of late-arriving T cells possessed the phenotype of central–memory cells, and proliferated more extensively during the secondary response than the progeny of the resident T cells. The results suggest that late arrival into lymph nodes and exposure to antigen-presenting cells displaying lower numbers of peptide–MHC II complexes in the presence of competing T cells ensures that some antigen-specific CD4(+) T cells divide less in the primary response and become central–memory cells.
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spelling pubmed-21182912007-12-13 CD4(+) T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells Catron, Drew M. Rusch, Lori K. Hataye, Jason Itano, Andrea A. Jenkins, Marc K. J Exp Med Articles We explored the relationship between the time of naive CD4(+) T cell exposure to antigen in the primary immune response and the quality of the memory cells produced. Naive CD4(+) T cells that migrated into the skin-draining lymph nodes after subcutaneous antigen injection accounted for about half of the antigen-specific population present at the peak of clonal expansion. These late-arriving T cells divided less and more retained the central–memory marker CD62L than the T cells that resided in the draining lymph nodes at the time of antigen injection. The fewer cell divisions were related to competition with resident T cells that expanded earlier in the response and a reduction in the number of dendritic cells displaying peptide–major histocompatibility complex (MHC) II complexes at later times after antigen injection. The progeny of late-arriving T cells possessed the phenotype of central–memory cells, and proliferated more extensively during the secondary response than the progeny of the resident T cells. The results suggest that late arrival into lymph nodes and exposure to antigen-presenting cells displaying lower numbers of peptide–MHC II complexes in the presence of competing T cells ensures that some antigen-specific CD4(+) T cells divide less in the primary response and become central–memory cells. The Rockefeller University Press 2006-04-17 /pmc/articles/PMC2118291/ /pubmed/16567390 http://dx.doi.org/10.1084/jem.20051954 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Catron, Drew M.
Rusch, Lori K.
Hataye, Jason
Itano, Andrea A.
Jenkins, Marc K.
CD4(+) T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells
title CD4(+) T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells
title_full CD4(+) T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells
title_fullStr CD4(+) T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells
title_full_unstemmed CD4(+) T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells
title_short CD4(+) T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells
title_sort cd4(+) t cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118291/
https://www.ncbi.nlm.nih.gov/pubmed/16567390
http://dx.doi.org/10.1084/jem.20051954
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