SAP regulates T cell–mediated help for humoral immunity by a mechanism distinct from cytokine regulation

X-linked lymphoproliferative disease is caused by mutations affecting SH2D1A/SAP, an adaptor that recruits Fyn to signal lymphocyte activation molecule (SLAM)-related receptors. After infection, SLAM-associated protein (SAP)(−/−) mice show increased T cell activation and impaired humoral responses....

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Detalles Bibliográficos
Autores principales: Cannons, Jennifer L., Yu, Li J., Jankovic, Dragana, Crotty, Shane, Horai, Reiko, Kirby, Martha, Anderson, Stacie, Cheever, Allen W., Sher, Alan, Schwartzberg, Pamela L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118305/
https://www.ncbi.nlm.nih.gov/pubmed/16754717
http://dx.doi.org/10.1084/jem.20052097

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