Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis

Caspase-1 is activated by a variety of stimuli after the assembly of the “inflammasome,” an activating platform made up of a complex of the NOD-LRR family of proteins. Caspase-1 is required for the secretion of proinflammatory cytokines, such as interleukin (IL)-1β and IL-18, and is involved in the...

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Autores principales: Lara-Tejero, Maria, Sutterwala, Fayyaz S., Ogura, Yasunori, Grant, Ethan P., Bertin, John, Coyle, Anthony J., Flavell, Richard A., Galán, Jorge E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118315/
https://www.ncbi.nlm.nih.gov/pubmed/16717117
http://dx.doi.org/10.1084/jem.20060206
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author Lara-Tejero, Maria
Sutterwala, Fayyaz S.
Ogura, Yasunori
Grant, Ethan P.
Bertin, John
Coyle, Anthony J.
Flavell, Richard A.
Galán, Jorge E.
author_facet Lara-Tejero, Maria
Sutterwala, Fayyaz S.
Ogura, Yasunori
Grant, Ethan P.
Bertin, John
Coyle, Anthony J.
Flavell, Richard A.
Galán, Jorge E.
author_sort Lara-Tejero, Maria
collection PubMed
description Caspase-1 is activated by a variety of stimuli after the assembly of the “inflammasome,” an activating platform made up of a complex of the NOD-LRR family of proteins. Caspase-1 is required for the secretion of proinflammatory cytokines, such as interleukin (IL)-1β and IL-18, and is involved in the control of many bacterial infections. Paradoxically, however, its absence has been reported to confer resistance to oral infection by Salmonella typhimurium. We show here that absence of caspase-1 or components of the inflammasome does not result in resistance to oral infection by S. typhimurium, but rather, leads to increased susceptibility to infection.
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spelling pubmed-21183152007-12-13 Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis Lara-Tejero, Maria Sutterwala, Fayyaz S. Ogura, Yasunori Grant, Ethan P. Bertin, John Coyle, Anthony J. Flavell, Richard A. Galán, Jorge E. J Exp Med Brief Definitive Reports Caspase-1 is activated by a variety of stimuli after the assembly of the “inflammasome,” an activating platform made up of a complex of the NOD-LRR family of proteins. Caspase-1 is required for the secretion of proinflammatory cytokines, such as interleukin (IL)-1β and IL-18, and is involved in the control of many bacterial infections. Paradoxically, however, its absence has been reported to confer resistance to oral infection by Salmonella typhimurium. We show here that absence of caspase-1 or components of the inflammasome does not result in resistance to oral infection by S. typhimurium, but rather, leads to increased susceptibility to infection. The Rockefeller University Press 2006-06-12 /pmc/articles/PMC2118315/ /pubmed/16717117 http://dx.doi.org/10.1084/jem.20060206 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Lara-Tejero, Maria
Sutterwala, Fayyaz S.
Ogura, Yasunori
Grant, Ethan P.
Bertin, John
Coyle, Anthony J.
Flavell, Richard A.
Galán, Jorge E.
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
title Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
title_full Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
title_fullStr Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
title_full_unstemmed Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
title_short Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
title_sort role of the caspase-1 inflammasome in salmonella typhimurium pathogenesis
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118315/
https://www.ncbi.nlm.nih.gov/pubmed/16717117
http://dx.doi.org/10.1084/jem.20060206
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