FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

Puma is an essential mediator of p53-dependent and -independent apoptosis in vivo. In response to genotoxic stress, Puma is induced in a p53-dependent manner. However, the transcription factor driving Puma up-regulation in response to p53-independent apoptotic stimuli has yet to be identified. Here,...

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Autores principales: You, Han, Pellegrini, Marc, Tsuchihara, Katsuya, Yamamoto, Kazuo, Hacker, Georg, Erlacher, Miriam, Villunger, Andreas, Mak, Tak W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118330/
https://www.ncbi.nlm.nih.gov/pubmed/16801400
http://dx.doi.org/10.1084/jem.20060353
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author You, Han
Pellegrini, Marc
Tsuchihara, Katsuya
Yamamoto, Kazuo
Hacker, Georg
Erlacher, Miriam
Villunger, Andreas
Mak, Tak W.
author_facet You, Han
Pellegrini, Marc
Tsuchihara, Katsuya
Yamamoto, Kazuo
Hacker, Georg
Erlacher, Miriam
Villunger, Andreas
Mak, Tak W.
author_sort You, Han
collection PubMed
description Puma is an essential mediator of p53-dependent and -independent apoptosis in vivo. In response to genotoxic stress, Puma is induced in a p53-dependent manner. However, the transcription factor driving Puma up-regulation in response to p53-independent apoptotic stimuli has yet to be identified. Here, we show that FOXO3a up-regulates Puma expression in response to cytokine or growth factor deprivation. Importantly, dysregulated Akt signaling in lymphoid cells attenuated Puma induction upon cytokine withdrawal. Our results suggest that Puma, together with another BH3 only member, Bim, function as FOXO3a downstream targets to mediate a stress response when PI3K/Akt signaling is down-regulated.
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spelling pubmed-21183302007-12-13 FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal You, Han Pellegrini, Marc Tsuchihara, Katsuya Yamamoto, Kazuo Hacker, Georg Erlacher, Miriam Villunger, Andreas Mak, Tak W. J Exp Med Brief Definitive Reports Puma is an essential mediator of p53-dependent and -independent apoptosis in vivo. In response to genotoxic stress, Puma is induced in a p53-dependent manner. However, the transcription factor driving Puma up-regulation in response to p53-independent apoptotic stimuli has yet to be identified. Here, we show that FOXO3a up-regulates Puma expression in response to cytokine or growth factor deprivation. Importantly, dysregulated Akt signaling in lymphoid cells attenuated Puma induction upon cytokine withdrawal. Our results suggest that Puma, together with another BH3 only member, Bim, function as FOXO3a downstream targets to mediate a stress response when PI3K/Akt signaling is down-regulated. The Rockefeller University Press 2006-07-10 /pmc/articles/PMC2118330/ /pubmed/16801400 http://dx.doi.org/10.1084/jem.20060353 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
You, Han
Pellegrini, Marc
Tsuchihara, Katsuya
Yamamoto, Kazuo
Hacker, Georg
Erlacher, Miriam
Villunger, Andreas
Mak, Tak W.
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
title FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
title_full FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
title_fullStr FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
title_full_unstemmed FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
title_short FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
title_sort foxo3a-dependent regulation of puma in response to cytokine/growth factor withdrawal
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118330/
https://www.ncbi.nlm.nih.gov/pubmed/16801400
http://dx.doi.org/10.1084/jem.20060353
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