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Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction

The chronic graft-versus-host (cGvH) reaction is a model of induced lupus caused by alloreactive CD4(+) T cells from a Bm-12 mouse in a C57BL/6 recipient. We used this cGvH reaction in C57BL/6 anti-DNA H chain transgenic mice, 56R/B6, to understand the structure, specificity, and origin of the induc...

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Detalles Bibliográficos
Autores principales:	Witsch, Esther J., Cao, Hong, Fukuyama, Hidehiro, Weigert, Martin
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118344/ https://www.ncbi.nlm.nih.gov/pubmed/16801398 http://dx.doi.org/10.1084/jem.20060075

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