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A major histocompatibility complex class I–dependent subset of memory phenotype CD8(+) cells
Most memory phenotype (MP) CD44(hi) CD8(+) cells are resting interleukin (IL)-15–dependent cells characterized by high expression of the IL-2/IL-15 receptor β (CD122). However, some MP CD8(+) cells have a CD122(lo) phenotype and are IL-15 independent. Here, evidence is presented that the CD122(lo) s...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118360/ https://www.ncbi.nlm.nih.gov/pubmed/16818671 http://dx.doi.org/10.1084/jem.20052495 |
Sumario: | Most memory phenotype (MP) CD44(hi) CD8(+) cells are resting interleukin (IL)-15–dependent cells characterized by high expression of the IL-2/IL-15 receptor β (CD122). However, some MP CD8(+) cells have a CD122(lo) phenotype and are IL-15 independent. Here, evidence is presented that the CD122(lo) subset of MP CD8(+) cells is controlled largely by major histocompatibility complex (MHC) class I molecules. Many of these cells display surface markers typical of recently activated T cells (CD62L(lo), CD69(hi), CD43(hi), and CD127(lo)) and show a high rate of background proliferation. Cells with this phenotype are highly enriched in common γ chain–deficient mice and absent from MHC-I(−/−) mice. Unlike CD122(hi) CD8(+) cells, CD122(lo) MP CD8(+) cells survive poorly after transfer to MHC-I(−/−) hosts and cease to proliferate. Although distinctly different from typical antigen-specific memory cells, CD122(lo) MP CD8(+) cells closely resemble the antigen-dependent memory CD8(+) cells found in chronic viral infections. |
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