Antiviral defense: interferons and beyond

Mice lacking the adaptor protein that initiates an antiviral response downstream of the RNA helicases retinoic acid–inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) have recently been described. These studies highlight the essential and nonredundant role of nucleic acid...

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Detalles Bibliográficos
Autores principales: Stetson, Daniel B., Medzhitov, Ruslan
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118364/
https://www.ncbi.nlm.nih.gov/pubmed/16880263
http://dx.doi.org/10.1084/jem.20061377
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author Stetson, Daniel B.
Medzhitov, Ruslan
author_facet Stetson, Daniel B.
Medzhitov, Ruslan
author_sort Stetson, Daniel B.
collection PubMed
description Mice lacking the adaptor protein that initiates an antiviral response downstream of the RNA helicases retinoic acid–inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) have recently been described. These studies highlight the essential and nonredundant role of nucleic acid recognition in the induction of type I interferon production and raise important questions regarding the nature of cell-autonomous virus detection in coordinating the antiviral response.
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spelling pubmed-21183642007-12-13 Antiviral defense: interferons and beyond Stetson, Daniel B. Medzhitov, Ruslan J Exp Med Commentaries Mice lacking the adaptor protein that initiates an antiviral response downstream of the RNA helicases retinoic acid–inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) have recently been described. These studies highlight the essential and nonredundant role of nucleic acid recognition in the induction of type I interferon production and raise important questions regarding the nature of cell-autonomous virus detection in coordinating the antiviral response. The Rockefeller University Press 2006-08-07 /pmc/articles/PMC2118364/ /pubmed/16880263 http://dx.doi.org/10.1084/jem.20061377 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Stetson, Daniel B.
Medzhitov, Ruslan
Antiviral defense: interferons and beyond
title Antiviral defense: interferons and beyond
title_full Antiviral defense: interferons and beyond
title_fullStr Antiviral defense: interferons and beyond
title_full_unstemmed Antiviral defense: interferons and beyond
title_short Antiviral defense: interferons and beyond
title_sort antiviral defense: interferons and beyond
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118364/
https://www.ncbi.nlm.nih.gov/pubmed/16880263
http://dx.doi.org/10.1084/jem.20061377
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