Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4(+) central memory T cells

The molecular events involved in the establishment and maintenance of CD4(+) central memory and effector memory T cells (T(CM) and T(EM), respectively) are poorly understood. In this study, we demonstrate that ex vivo isolated T(CM) are more resistant to both spontaneous and Fas-induced apoptosis th...

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Detalles Bibliográficos
Autores principales: Riou, Catherine, Yassine-Diab, Bader, Van grevenynghe, Julien, Somogyi, Roland, Greller, Larry D., Gagnon, Dominic, Gimmig, Sylvain, Wilkinson, Peter, Shi, Yu, Cameron, Mark J., Campos-Gonzalez, Roberto, Balderas, Robert S., Kelvin, David, Sekaly, Rafick-Pierre, Haddad, Elias K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118424/
https://www.ncbi.nlm.nih.gov/pubmed/17190839
http://dx.doi.org/10.1084/jem.20061681

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