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DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2–MSH6 proteins, together with DNA polymerase η (pol η). However, residual A/T mutagenesis is still observed up...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118439/ https://www.ncbi.nlm.nih.gov/pubmed/17190840 http://dx.doi.org/10.1084/jem.20062131 |