The yin and yang of intestinal epithelial cells in controlling dendritic cell function

Recent work suggests that dendritic cells (DCs) in mucosal tissues are “educated” by intestinal epithelial cells (IECs) to suppress inflammation and promote immunological tolerance. After attack by pathogenic microorganisms, however, “non-educated” DCs are recruited from nearby areas, such as the do...

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Detalles Bibliográficos
Autores principales: Iliev, Iliyan D., Matteoli, Gianluca, Rescigno, Maria
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118441/
https://www.ncbi.nlm.nih.gov/pubmed/17893197
http://dx.doi.org/10.1084/jem.20062535
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author Iliev, Iliyan D.
Matteoli, Gianluca
Rescigno, Maria
author_facet Iliev, Iliyan D.
Matteoli, Gianluca
Rescigno, Maria
author_sort Iliev, Iliyan D.
collection PubMed
description Recent work suggests that dendritic cells (DCs) in mucosal tissues are “educated” by intestinal epithelial cells (IECs) to suppress inflammation and promote immunological tolerance. After attack by pathogenic microorganisms, however, “non-educated” DCs are recruited from nearby areas, such as the dome of Peyer's patches (PPs) and the blood, to initiate inflammation and the ensuing immune response to the invader. Differential epithelial cell (EC) responses to commensals and pathogens may control these two tolorogenic and immunogenic functions of DCs.
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spelling pubmed-21184412008-04-01 The yin and yang of intestinal epithelial cells in controlling dendritic cell function Iliev, Iliyan D. Matteoli, Gianluca Rescigno, Maria J Exp Med Commentaries Recent work suggests that dendritic cells (DCs) in mucosal tissues are “educated” by intestinal epithelial cells (IECs) to suppress inflammation and promote immunological tolerance. After attack by pathogenic microorganisms, however, “non-educated” DCs are recruited from nearby areas, such as the dome of Peyer's patches (PPs) and the blood, to initiate inflammation and the ensuing immune response to the invader. Differential epithelial cell (EC) responses to commensals and pathogens may control these two tolorogenic and immunogenic functions of DCs. The Rockefeller University Press 2007-10-01 /pmc/articles/PMC2118441/ /pubmed/17893197 http://dx.doi.org/10.1084/jem.20062535 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Iliev, Iliyan D.
Matteoli, Gianluca
Rescigno, Maria
The yin and yang of intestinal epithelial cells in controlling dendritic cell function
title The yin and yang of intestinal epithelial cells in controlling dendritic cell function
title_full The yin and yang of intestinal epithelial cells in controlling dendritic cell function
title_fullStr The yin and yang of intestinal epithelial cells in controlling dendritic cell function
title_full_unstemmed The yin and yang of intestinal epithelial cells in controlling dendritic cell function
title_short The yin and yang of intestinal epithelial cells in controlling dendritic cell function
title_sort yin and yang of intestinal epithelial cells in controlling dendritic cell function
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118441/
https://www.ncbi.nlm.nih.gov/pubmed/17893197
http://dx.doi.org/10.1084/jem.20062535
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