Structural basis for complement factor H–linked age-related macular degeneration

Nearly 50 million people worldwide suffer from age-related macular degeneration (AMD), which causes severe loss of central vision. A single-nucleotide polymorphism in the gene for the complement regulator factor H (FH), which causes a Tyr-to-His substitution at position 402, is linked to ∼50% of att...

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Detalles Bibliográficos
Autores principales: Prosser, Beverly E., Johnson, Steven, Roversi, Pietro, Herbert, Andrew P., Blaum, Bärbel S., Tyrrell, Jess, Jowitt, Thomas A., Clark, Simon J., Tarelli, Edward, Uhrín, Dušan, Barlow, Paul N., Sim, Robert B., Day, Anthony J., Lea, Susan M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118454/
https://www.ncbi.nlm.nih.gov/pubmed/17893204
http://dx.doi.org/10.1084/jem.20071069

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