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Different composition of the human and the mouse γδ T cell receptor explains different phenotypes of CD3γ and CD3δ immunodeficiencies

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The γδ T cell receptor for antigen (TCR) comprises the clonotypic TCRγδ, the CD3 (CD3γε and/or CD3δε), and the ζζ dimers. γδ T cells do not develop in CD3γ-deficient mice, whereas human patients lacking CD3γ have abundant peripheral blood γδ T cells expressing high γδ TCR levels. In an attempt to id...

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Detalles Bibliográficos
Autores principales:	Siegers, Gabrielle M., Swamy, Mahima, Fernández-Malavé, Edgar, Minguet, Susana, Rathmann, Sylvia, Guardo, Alberto C., Pérez-Flores, Verónica, Regueiro, Jose R., Alarcón, Balbino, Fisch, Paul, Schamel, Wolfgang W.A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Brief Definitive Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118495/ https://www.ncbi.nlm.nih.gov/pubmed/17923503 http://dx.doi.org/10.1084/jem.20070782

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