Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast cancer. However, the reason that Jagged1 and/or Notch overexpression portends a poor prognosis is unknown. We identify Slug, a transcriptional repressor, as a novel Notch target and show that elevated levels of Slug...

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Detalles Bibliográficos
Autores principales: Leong, Kevin G., Niessen, Kyle, Kulic, Iva, Raouf, Afshin, Eaves, Connie, Pollet, Ingrid, Karsan, Aly
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118507/
https://www.ncbi.nlm.nih.gov/pubmed/17984306
http://dx.doi.org/10.1084/jem.20071082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118507/
https://www.ncbi.nlm.nih.gov/pubmed/17984306
http://dx.doi.org/10.1084/jem.20071082

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