APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination

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Antibody class switch recombination (CSR) occurs by an intrachromosomal deletion requiring generation of double-stranded breaks (DSBs) in switch-region DNA. The initial steps in DSB formation have been elucidated, involving cytosine deamination by activation-induced cytidine deaminase and generation...

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Detalles Bibliográficos
Autores principales: Guikema, Jeroen E.J., Linehan, Erin K., Tsuchimoto, Daisuke, Nakabeppu, Yusaku, Strauss, Phyllis R., Stavnezer, Janet, Schrader, Carol E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118529/
https://www.ncbi.nlm.nih.gov/pubmed/18025127
http://dx.doi.org/10.1084/jem.20071289

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