IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Igα/β

We describe a mouse strain in which B cell development relies either on the expression of membrane-bound immunoglobulin (Ig) γ1 or μ heavy chains. Progenitor cells expressing γ1 chains from the beginning generate a peripheral B cell compartment of normal size with all subsets, but a partial block is...

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Detalles Bibliográficos
Autores principales: Waisman, Ari, Kraus, Manfred, Seagal, Jane, Ghosh, Snigdha, Melamed, Doron, Song, Jian, Sasaki, Yoshiteru, Classen, Sabine, Lutz, Claudia, Brombacher, Frank, Nitschke, Lars, Rajewsky, Klaus
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118546/
https://www.ncbi.nlm.nih.gov/pubmed/17420268
http://dx.doi.org/10.1084/jem.20062024

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