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De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells
DNA methylation is an epigenetic modification essential for development. The DNA methyltransferases Dnmt3a and Dnmt3b execute de novo DNA methylation in gastrulating embryos and differentiating germline cells. It has been assumed that these enzymes generally play a role in regulating cell differenti...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118548/ https://www.ncbi.nlm.nih.gov/pubmed/17420264 http://dx.doi.org/10.1084/jem.20060750 |