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Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis
Mouse cytomegalovirus (MCMV) susceptibility often results from defects of natural killer (NK) cell function. Here we describe Jinx, an N-ethyl-N-nitrosourea–induced MCMV susceptibility mutation that permits unchecked proliferation of the virus, causing death. In Jinx homozygotes, activated NK cells...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118559/ https://www.ncbi.nlm.nih.gov/pubmed/17420270 http://dx.doi.org/10.1084/jem.20062447 |
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por Crozat, Karine, Hoebe, Kasper, Ugolini, Sophie, Hong, Nancy A., Janssen, Edith, Rutschmann, Sophie, Mudd, Suzanne, Sovath, Sosathya, Vivier, Eric, Beutler, Bruce
Publicado 2008
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Publicado 2008
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Texto