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Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers

We describe a mouse model of fetal loss in factor V Leiden (FvL) mothers in which fetal loss is triggered when the maternal prothrombotic state coincides with fetal gene defects that reduce activation of the protein C anticoagulant pathway within the placenta. Fetal loss is caused by disruption of p...

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Detalles Bibliográficos
Autores principales:	Sood, Rashmi, Zogg, Mark, Westrick, Randal J., Guo, Yi-he, Kerschen, Edward J., Girardi, Guillermina, Salmon, Jane E., Coughlin, Shaun R., Weiler, Hartmut
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118565/ https://www.ncbi.nlm.nih.gov/pubmed/17438064 http://dx.doi.org/10.1084/jem.20062566

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