The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation

CD1d-restricted lymphocytes recognize a broad lipid range. However, how CD1d-restricted lymphocytes translate T cell receptor (TCR) recognition of lipids with similar group heads into distinct biological responses remains unclear. Using a soluble invariant NKT (iNKT) TCR and a newly engineered antib...

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Detalles Bibliográficos
Autores principales: McCarthy, Corinna, Shepherd, Dawn, Fleire, Sebastian, Stronge, Victoria S., Koch, Michael, Illarionov, Petr A., Bossi, Giovanna, Salio, Mariolina, Denkberg, Galit, Reddington, Faye, Tarlton, Andrea, Reddy, B. Gopal, Schmidt, Richard R., Reiter, Yoram, Griffiths, Gillian M., van der Merwe, P. Anton, Besra, Gurdyal S., Jones, E. Yvonne, Batista, Facundo D., Cerundolo, Vincenzo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118584/
https://www.ncbi.nlm.nih.gov/pubmed/17485514
http://dx.doi.org/10.1084/jem.20062342

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