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Lymphomas can develop from B cells chronically helped by idiotype-specific T cells

B cell lymphomas have been associated with chronic infections and autoimmunity. However, most lymphomas develop in the absence of any known chronic antigenic stimulation. B cells process their highly diversified endogenous immunoglobulin and present clonally unique variable-region idiotypic (Id) pep...

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Autores principales: Zangani, Michael M., Frøyland, Marianne, Qiu, Gao Yue, Meza-Zepeda, Leonardo A., Kutok, Jeffery L., Thompson, Keith M., Munthe, Ludvig A., Bogen, Bjarne
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118585/
https://www.ncbi.nlm.nih.gov/pubmed/17485509
http://dx.doi.org/10.1084/jem.20061220
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author Zangani, Michael M.
Frøyland, Marianne
Qiu, Gao Yue
Meza-Zepeda, Leonardo A.
Kutok, Jeffery L.
Thompson, Keith M.
Munthe, Ludvig A.
Bogen, Bjarne
author_facet Zangani, Michael M.
Frøyland, Marianne
Qiu, Gao Yue
Meza-Zepeda, Leonardo A.
Kutok, Jeffery L.
Thompson, Keith M.
Munthe, Ludvig A.
Bogen, Bjarne
author_sort Zangani, Michael M.
collection PubMed
description B cell lymphomas have been associated with chronic infections and autoimmunity. However, most lymphomas develop in the absence of any known chronic antigenic stimulation. B cells process their highly diversified endogenous immunoglobulin and present clonally unique variable-region idiotypic (Id) peptides on their major histocompatibility complex (MHC) class II molecules to Id-specific T cells. We show that B cells chronically helped by Id-specific Th2 cells developed into large B cell lymphomas with cytogenetic DNA aberrations. The lymphomas expressed high amounts of Id, MHC class II, CD80/86, and CD40 and bidirectionally collaborated with Th2 cells. Thus, MHC class II–presented Id peptides may represent a chronic self-antigenic stimulus for T cell–dependent lymphomagenesis. Eventually, B lymphomas grew independent of T cells. Thus, T cells do not only eliminate cancers as currently believed. In fact, Id-specific Th2 cells can induce B lymphomas.
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spelling pubmed-21185852007-12-13 Lymphomas can develop from B cells chronically helped by idiotype-specific T cells Zangani, Michael M. Frøyland, Marianne Qiu, Gao Yue Meza-Zepeda, Leonardo A. Kutok, Jeffery L. Thompson, Keith M. Munthe, Ludvig A. Bogen, Bjarne J Exp Med Articles B cell lymphomas have been associated with chronic infections and autoimmunity. However, most lymphomas develop in the absence of any known chronic antigenic stimulation. B cells process their highly diversified endogenous immunoglobulin and present clonally unique variable-region idiotypic (Id) peptides on their major histocompatibility complex (MHC) class II molecules to Id-specific T cells. We show that B cells chronically helped by Id-specific Th2 cells developed into large B cell lymphomas with cytogenetic DNA aberrations. The lymphomas expressed high amounts of Id, MHC class II, CD80/86, and CD40 and bidirectionally collaborated with Th2 cells. Thus, MHC class II–presented Id peptides may represent a chronic self-antigenic stimulus for T cell–dependent lymphomagenesis. Eventually, B lymphomas grew independent of T cells. Thus, T cells do not only eliminate cancers as currently believed. In fact, Id-specific Th2 cells can induce B lymphomas. The Rockefeller University Press 2007-05-14 /pmc/articles/PMC2118585/ /pubmed/17485509 http://dx.doi.org/10.1084/jem.20061220 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Zangani, Michael M.
Frøyland, Marianne
Qiu, Gao Yue
Meza-Zepeda, Leonardo A.
Kutok, Jeffery L.
Thompson, Keith M.
Munthe, Ludvig A.
Bogen, Bjarne
Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
title Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
title_full Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
title_fullStr Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
title_full_unstemmed Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
title_short Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
title_sort lymphomas can develop from b cells chronically helped by idiotype-specific t cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118585/
https://www.ncbi.nlm.nih.gov/pubmed/17485509
http://dx.doi.org/10.1084/jem.20061220
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