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Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
B cell lymphomas have been associated with chronic infections and autoimmunity. However, most lymphomas develop in the absence of any known chronic antigenic stimulation. B cells process their highly diversified endogenous immunoglobulin and present clonally unique variable-region idiotypic (Id) pep...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118585/ https://www.ncbi.nlm.nih.gov/pubmed/17485509 http://dx.doi.org/10.1084/jem.20061220 |
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author | Zangani, Michael M. Frøyland, Marianne Qiu, Gao Yue Meza-Zepeda, Leonardo A. Kutok, Jeffery L. Thompson, Keith M. Munthe, Ludvig A. Bogen, Bjarne |
author_facet | Zangani, Michael M. Frøyland, Marianne Qiu, Gao Yue Meza-Zepeda, Leonardo A. Kutok, Jeffery L. Thompson, Keith M. Munthe, Ludvig A. Bogen, Bjarne |
author_sort | Zangani, Michael M. |
collection | PubMed |
description | B cell lymphomas have been associated with chronic infections and autoimmunity. However, most lymphomas develop in the absence of any known chronic antigenic stimulation. B cells process their highly diversified endogenous immunoglobulin and present clonally unique variable-region idiotypic (Id) peptides on their major histocompatibility complex (MHC) class II molecules to Id-specific T cells. We show that B cells chronically helped by Id-specific Th2 cells developed into large B cell lymphomas with cytogenetic DNA aberrations. The lymphomas expressed high amounts of Id, MHC class II, CD80/86, and CD40 and bidirectionally collaborated with Th2 cells. Thus, MHC class II–presented Id peptides may represent a chronic self-antigenic stimulus for T cell–dependent lymphomagenesis. Eventually, B lymphomas grew independent of T cells. Thus, T cells do not only eliminate cancers as currently believed. In fact, Id-specific Th2 cells can induce B lymphomas. |
format | Text |
id | pubmed-2118585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21185852007-12-13 Lymphomas can develop from B cells chronically helped by idiotype-specific T cells Zangani, Michael M. Frøyland, Marianne Qiu, Gao Yue Meza-Zepeda, Leonardo A. Kutok, Jeffery L. Thompson, Keith M. Munthe, Ludvig A. Bogen, Bjarne J Exp Med Articles B cell lymphomas have been associated with chronic infections and autoimmunity. However, most lymphomas develop in the absence of any known chronic antigenic stimulation. B cells process their highly diversified endogenous immunoglobulin and present clonally unique variable-region idiotypic (Id) peptides on their major histocompatibility complex (MHC) class II molecules to Id-specific T cells. We show that B cells chronically helped by Id-specific Th2 cells developed into large B cell lymphomas with cytogenetic DNA aberrations. The lymphomas expressed high amounts of Id, MHC class II, CD80/86, and CD40 and bidirectionally collaborated with Th2 cells. Thus, MHC class II–presented Id peptides may represent a chronic self-antigenic stimulus for T cell–dependent lymphomagenesis. Eventually, B lymphomas grew independent of T cells. Thus, T cells do not only eliminate cancers as currently believed. In fact, Id-specific Th2 cells can induce B lymphomas. The Rockefeller University Press 2007-05-14 /pmc/articles/PMC2118585/ /pubmed/17485509 http://dx.doi.org/10.1084/jem.20061220 Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Zangani, Michael M. Frøyland, Marianne Qiu, Gao Yue Meza-Zepeda, Leonardo A. Kutok, Jeffery L. Thompson, Keith M. Munthe, Ludvig A. Bogen, Bjarne Lymphomas can develop from B cells chronically helped by idiotype-specific T cells |
title | Lymphomas can develop from B cells chronically helped by idiotype-specific T cells |
title_full | Lymphomas can develop from B cells chronically helped by idiotype-specific T cells |
title_fullStr | Lymphomas can develop from B cells chronically helped by idiotype-specific T cells |
title_full_unstemmed | Lymphomas can develop from B cells chronically helped by idiotype-specific T cells |
title_short | Lymphomas can develop from B cells chronically helped by idiotype-specific T cells |
title_sort | lymphomas can develop from b cells chronically helped by idiotype-specific t cells |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118585/ https://www.ncbi.nlm.nih.gov/pubmed/17485509 http://dx.doi.org/10.1084/jem.20061220 |
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