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Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis

The chromosomal instability syndromes Nijmegen breakage syndrome (NBS) and ataxia telangiectasia (AT) share many overlapping phenotypes, including cancer predisposition, radiation sensitivity, cell-cycle checkpoint defects, immunodeficiency, and gonadal dysfunction. The NBS protein Nbs1 is not only...

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Detalles Bibliográficos
Autores principales:	Difilippantonio, Simone, Celeste, Arkady, Kruhlak, Michael J., Lee, Youngsoo, Difilippantonio, Michael J., Feigenbaum, Lionel, Jackson, Stephen P., McKinnon, Peter J., Nussenzweig, André
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Brief Definitive Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118591/ https://www.ncbi.nlm.nih.gov/pubmed/17485521 http://dx.doi.org/10.1084/jem.20070319

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