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Th2-driven, allergen-induced airway inflammation is reduced after treatment with anti–Tim-3 antibody in vivo
T cell immunoglobulin and mucin domain–containing molecule-3 (Tim-3) is a surface molecule that is preferentially expressed on activated Th1 cells in comparison to Th2 cells. Blockade of Tim-3 has been shown to enhance Th1-driven pathology in vivo, suggesting that blockade of Tim-3 may improve the d...
Autores principales: | Kearley, Jennifer, McMillan, Sarah J., Lloyd, Clare M. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118608/ https://www.ncbi.nlm.nih.gov/pubmed/17517968 http://dx.doi.org/10.1084/jem.20062093 |
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