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Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes

Ataxia-telangiectasia mutated (ATM)–deficient lymphocytes exhibit defects in coding joint formation during V(D)J recombination in vitro. Similar defects in vivo should affect both T and B cell development, yet the lymphoid phenotypes of ATM deficiency are more pronounced in the T cell compartment. I...

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Detalles Bibliográficos
Autores principales:	Huang, Ching-Yu, Sharma, Girdhar G., Walker, Laura M., Bassing, Craig H., Pandita, Tej K., Sleckman, Barry P.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118620/ https://www.ncbi.nlm.nih.gov/pubmed/17502661 http://dx.doi.org/10.1084/jem.20061460

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